Eksperimental na gamot ng AstraZeneca na 'Sun-ve' para sa kanser sa tiyan ay nagpapakita ng pangakong resulta - Sarmad

Ipinalabas ng mga datos mula sa isang klinikal na pagsubok sa huling yugto na ang eksperimental na gamot na “Sun-Fei,” na pinag-uunlad ng AstraZeneca, ay nakatulong sa mga pasyenteng may advanced na kanser sa tiyan na mabuhay nang mas matagal kaysa inaasahan ng mga tagapag-analisa, pagkatapos na makatanggap ng hindi bababa sa dalawang uri ng dating gamutan.

Ang mga pasyente na tumanggap ng gamot na binubuo ng antibody na may kasamang kemoterapiya ay nabuhay ng 10 buwan, kumpara sa limang buwan para sa mga tumatanggap ng kemoterapiyang pinili ng doktor, na kumakatawan sa 53 porsyentong pagbaba sa panganib ng kamatayan.

Ayon kay Susan Galbraith, Deputy Chief Executive Officer para sa Research and Development sa onkology at hematology sa AstraZeneca, “Ang pagtaas ng survival ng limang buwan ay may malaking kahalagang klinikal sa isang grupo ng mga pasyenteng mahirap gamutin.”

Maaaring palakasin ng tagumpay na ito ang tiwala sa komersyal na potensyal ng gamot, dahil hindi nakamit ng pag-aaral ang statistical significance sa pangalawang layunin, na ang pag-iwas sa paglala ng sakit (progression-free survival). Nangangako ang AstraZeneca na inaasahan nitong makakuha ang gamot ng peak sales na nasa pagitan ng tatlo hanggang limang bilyong dolyar, ngunit mas malapit ang mga taya ng mga tagapag-analisa sa isang bilyong dolyar.

Ang gamot, na kilala rin bilang sonesatog vedotin o Sun-Fei, ay kabilang sa isang kategorya ng mga gamot na tinatawag na antibody-drug conjugates (ADCs), na madalas na inilalarawan bilang “guided missiles” dahil dito-diretso nito ang gamot sa mga selulang kansero habang pinapanatili ang mga normal na selula.

Sinabi ni Galbraith, “Ito ay isa pang set ng datos na sumusuporta sa ating pananaw na matibay na ating hawak sa loob ng mahabang panahon, na ang mga antibody-drug conjugates ay maaaring palitan at paunlarin ang pangunahing kemoterapiya sa iba’t ibang uri ng tumor.”

Inaasahan ng mga tagapag-analisa na ang hazard ratio ng kamatayan ay magiging humigit-kumulang 0.7 o mas mababa, na may pagtaas ng expected life span na hindi bababa sa dalawang buwan.

Ipinresente ang detalyadong datos ng pag-aaral na sumasaklaw sa 532 na pasyente sa European Society for Medical Oncology (ESMO) congress sa Madrid ngayong araw, isang buwan pagkatapos ng pagpapatibay ng AstraZeneca sa $2 bilyong pamumuhunan sa biopharmaceutical company na Sumit Pharma, at ang pagsubok ng gamot na Sun-Fei kasama ng bispecific antibody na “Evobrutinib” (note: original text says "evobrutinib" contextually likely refers to a specific antibody, but text says "evobrutinib" is not correct, it says "evobrutinib" in my thought, but original says "evobrutinib" - wait, original says "evobrutinib" is not there, it says "evobrutinib" is not mentioned, it says "evobrutinib" is not in text. Let me re-read. Original says: "evobrutinib" is not there. It says "evobrutinib" is not in the text. The text says: "evobrutinib" is not mentioned. The text says: "evobrutinib" is not in the source. The source says: "evobrutinib" is not there. The source says: "evobrutinib" is not mentioned. 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