Health World

A recent study has shown that neohesperidin, a compound found in citrus fruits, can combat fat accumulation in the liver and improve overall fat metabolism in the body. Scientists investigated the effects of neohesperidin on metabolic dysfunction-associated steatotic liver disease (MASLD) cells, a condition resulting from a diet high in fats. The experiments demonstrated that the compound significantly reduced fat accumulation in liver cells and alleviated disease symptoms in laboratory animals.

Researchers discovered that neohesperidin binds to the ECHS1 protein, a key enzyme involved in the breakdown of fatty acids. This protein binding protects ECHS1 from degradation, enhances fat burning, and simultaneously activates the PPARA signaling pathway, which plays a crucial role in regulating the body’s fat metabolism.

Researchers believe that ECHS1 could represent a new therapeutic target for fatty liver disease, and that neohesperidin may be the first compound capable of directly stabilizing this protein. To prevent fatty liver disease, doctors recommend following a healthy, low-fat, low-calorie diet, exercising regularly, and avoiding foods high in sugars.

Source: Lenta.ru